PLENVU® offers patients a more positive prep experience1,2,*
- Very acceptable: 15.2%, PLENVU® vs 7.5%, Suprep1,2
- Very acceptable or acceptable: 66.7%, PLENVU® vs 50.7%, Suprep1
See full NOCT trial details.
*Based on patient diary ratings related to acceptability of taste1
†Based on a post hoc analysis2
PLENVU® demonstrated high patient satisfaction overall
Results from a real-world, prospective, online US survey3,‡
How easy was it for you to prepare and take PLENVU®?
76%
(n=1598)
of patients rated PLENVU® “very easy” to prepare and take3,§
How satisfied were you with PLENVU® overall?
90%
(n=1598)
of patients were very or moderately satisfied overall|| with PLENVU®3,¶
‡Salix-sponsored post-marketing patient survey results collected up to 2 weeks post-colonoscopy. Over 1600 patients were provided PLENVU® samples for colonoscopy and 707 healthcare providers were recruited from gastroenterology practices from across the United States to share their experience with PLENVU®. Patients were compensated for their time with a $20 gift card. Survey questions were scored on 9-point grading scale with high scores (7-9) indicating strong favorable rating for PLENVU®, mid-range scores (4-6) were intermediate, and low scores (1-3) were negative. Patients were asked to provide specific demographic information and relevant history, and to report their experiences with PLENVU®. Patients who previously had colonoscopies were asked to recall how their PLENVU® experiences compared to any previously used preps. No statistical tests were run in this survey and as a result, no statistically significant difference can be inferred3
§76% representative of patients who indicated scores of 7-9 on a 9-point scale3
||Overall satisfaction was based on product tolerability (ie, volume and taste)3
¶90% representative of patients who indicated scores of 4-9 on a 9-point scale3
PLENVU® from a patient point of VU
Hear these patients review their personal bowel prep experiences with PLENVU®
These testimonials are from real patients who were prescribed PLENVU®.
These testimonials are from real patients who were prescribed PLENVU®.
References: 1. DeMicco MP et al. Gastrointest Endosc. 2018;87(3):677-687.e3. 2. Data on file. Salix Pharmaceuticals. 3. Cash BD et al. BMC Gastroenterol. 2021;21(1):1-8.
INDICATION
PLENVU® (polyethylene glycol 3350, sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride and potassium chloride for oral solution) is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults.
IMPORTANT SAFETY INFORMATION
- PLENVU® is contraindicated in patients with gastrointestinal (GI) obstruction, bowel perforation, gastric retention, ileus, toxic megacolon, and hypersensitivity to any of its ingredients.
- Advise patients to hydrate adequately before, during, and after the use of PLENVU®. It is encouraged that patients drink additional clear liquids to help avoid cases of fluid and electrolyte abnormalities. Fluid and electrolyte disturbances can lead to serious adverse events including cardiac arrhythmias, seizures, and renal impairment.
- There have been rare reports of serious arrhythmias associated with the use of ionic osmotic laxative products for bowel preparation. These occur predominantly in patients with underlying cardiac risk factors and electrolyte disturbances. Consider obtaining ECGs in patients at an increased risk of serious cardiac arrhythmias.
- Use PLENVU® with caution in patients with a history of seizures and those at an increased risk of seizures, including patients taking medications that lower the seizure threshold, patients withdrawing from alcohol or benzodiazepines, or patients with hyponatremia.
- Use PLENVU® with caution in patients with renal impairment or those taking concomitant medications that affect renal function. Advise these patients to adequately hydrate before, during, and after the use of PLENVU® and consider performing laboratory tests in these patients.
- Do not administer PLENVU® to patients with GI obstruction or perforation. If GI obstruction or perforation is suspected, perform appropriate diagnostic studies prior to administering PLENVU®.
- Use caution in patients with severe ulcerative colitis.
- Patients with impaired gag reflex or those prone to regurgitation or aspiration should be observed during the administration of PLENVU®. Use with caution in these patients. Do not combine PLENVU® with starch-based thickeners.
- Use PLENVU® with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- Phenylalanine can be harmful to patients with phenylketonuria (PKU). PLENVU® contains phenylalanine, a component of aspartame. Each PLENVU® treatment contains 491 mg of phenylalanine.
- PLENVU® contains polyethylene glycol and may cause serious hypersensitivity reactions including anaphylaxis, angioedema, rash, urticaria, and pruritus. Inform patients of the signs and symptoms of anaphylaxis and instruct them to seek immediate medical care should signs and symptoms occur.
- In clinical trials, the most common adverse reactions (>2% of patients taking PLENVU®) were nausea, vomiting, dehydration, and abdominal pain/discomfort. Adverse reactions were similar between the two dosing regimens.
To report SUSPECTED ADVERSE REACTIONS, contact Salix Pharmaceuticals at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Please click here for full Prescribing Information.
INDICATION
PLENVU® (polyethylene glycol 3350, sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride and potassium chloride for oral solution) is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults.
IMPORTANT SAFETY INFORMATION
PLENVU® is contraindicated in patients with gastrointestinal (GI) obstruction, bowel perforation, gastric retention, ileus, toxic megacolon, and hypersensitivity to any of its ingredients.
